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Long-term studies are limited, but short-term use (up to six months) has shown significant benefits

This framework is intended as a conceptual guide rather than a deterministic regulatory algorithm

To improve transparency, Supplementary Table 7 summarizes molecule-specific pharmacokinetic and clinical considerations, including approximate half-life, label-informed discontinuation or washout recommendations before planned conception, representative human pregnancy-exposure evidence, reported adverse outcomes, and an interpretive certainty judgment

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